The must integrate:
: Abdominal ultrasounds and chest radiographs every 3 months for the first 2 years post-treatment.
Ultrasound of the abdomen, followed by a contrast-enhanced CT or MRI to determine the origin of the mass and evaluate the extent of the tumor.
: Standard procedure involving complete removal of the affected kidney and ureter.
Derived from persistent metanephric blastema (embryonic kidney precursor cells) and classically exhibits a triphasic histologic pattern (blastemal, stromal, and epithelial components).
: Most often diagnosed in children aged 3 to 4 years, becoming significantly less common after age 5. Statistics
: Arises from abnormal proliferation of renal embryonal cells (metanephric blastema).
: Medical Students, Pediatric Residents, and Oncology Fellows Slide 2: Executive Summary & Definition
Favorable histology shows the classic triphasic pattern consisting of blastemal, stromal, and epithelial cells. This group has a high cure rate. Unfavorable histology is characterized by anaplasia—extreme nuclear pleomorphism and hyperchromasia. Anaplasia is a significant predictor of resistance to chemotherapy and a poorer prognosis.
